Principal Scientist, Modeling & Simulation RLT
Company: Novartis Farmac--utica
Location: Cambridge
Posted on: October 18, 2024
Job Description:
Principal Scientist, Modeling & Simulation RLTJob ID:
REQ-10019028Date: Sep 03, 2024Location: USASummaryPrincipal
Scientist I/II, Radioligand Modeling & Simulation. This position
will be located in Cambridge, MA and will not have the ability to
be located remotely.About the RoleWe are seeking a translational or
clinical modeler eager to accelerate radioligand discovery &
development by facilitating rigorous decision making with modeling
& simulation. You will work in a multi-disciplinary environment,
with opportunities to engage in cross-functional initiatives. This
role reports to a PK Sciences Translational Modeling team lead, in
a group situated within Biomedical Research, the research engine of
Novartis.Key Responsibilities:
- Act as the Translational M&S representative on radioligand
therapy programs, developing and executing modeling strategies,
contributing to project team discussions, and guiding therapeutic
design and dose selection decisions.
- Build and apply innovative QSP and physiologically based PK
(PBPK) models along with dosimetry estimations to link RLT
pharmacology, tissue biodistribution, mechanism(s) of action, and
biological and clinical outcomes.
- Contribute to an integrated RLT modeling platform that bridges
data and knowledge across preclinical species and patients,
partnering with discovery project teams as well as the preclinical
safety and pharmacometrics groups.
- Implement innovative quantitative approaches to advance the
translational science for radiopharmaceuticals.
- Proactively seek opportunities to increase the impact and
awareness of translational and clinical modeling through
communications with internal and external audiences.
- Ph.D. in biology, pharmaceutical sciences, bioengineering,
biophysics, or a related field along with demonstrated expertise in
radiobiology / nuclear medicine. To be considered at the Principal
Scientist II level must have 2-3 years plus related experience
ideally in industry.
- Prior experience in pharmacokinetics and pharmacodynamics
(PK/PD), quantitative systems pharmacology (QSP), and/or
physiologically based PK (PBPK) modeling is preferred.
- Expert level proficiency in core modeling fundamentals is
required, including scripting languages (e.g., MATLAB, R),
construction of ordinary differential equation (ODE) models,
parameter estimation, and data visualization.
- Demonstrated ability to communicate modeling results to a
multidisciplinary audience to facilitate decision-making.
- To be considered as a Principal Scientist II must have
demonstrated ability and experience leading modeling projects with
drug discovery/development project teams, generating innovative
ideas and objectives within a team, and coaching/mentoring junior
modelers.
- Fluent in English (oral and written).This is a dual level
posting. The final level and title of the offer role would be
determined by the hiring team based on the skills, experience &
capabilities required to perform the role at the level the role has
been offered.Benefits and Rewards:Read our handbook to learn about
all the ways we'll help you thrive personally and professionally:
Novartis Life Handbook.Commitment to Diversity and
Inclusion:Novartis is committed to building an outstanding,
inclusive work environment and diverse teams representative of the
patients and communities we serve.The Novartis Group of Companies
are Equal Opportunity Employers who are focused on building and
advancing a culture of inclusion that values and celebrates
individual differences, uniqueness, backgrounds, and
perspectives.Accessibility & Reasonable AccommodationsThe Novartis
Group of Companies are committed to working with and providing
reasonable accommodation to individuals with disabilities. If,
because of a medical condition or disability, you need a reasonable
accommodation for any part of the application process, or to
perform the essential functions of a position, please send an
e-mail to us.reasonableaccommodations@novartis.com or call
+1(877)395-2339 and let us know the nature of your request and your
contact information. Please include the job requisition number in
your message.Division: Biomedical ResearchBusiness Unit: Pharma
ResearchLocation: USASite: Cambridge (USA)Company / Legal Entity:
U175 (FCRS = US175) Novartis Institutes for BioMedical Research,
Inc.
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Keywords: Novartis Farmac--utica, Plymouth , Principal Scientist, Modeling & Simulation RLT, Other , Cambridge, Massachusetts
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